Monthly Archives: January 2008

30 01, 2008
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    Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats.

Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats.

By |January 30th, 2008|Publicacions|0 Comments|

Marsillach J, Ferré N, Camps J, Rull A, Beltran R, Joven J.

Source
Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut de Recerca en Ciències de la Salut, C. Sant Joan s/n, 43201 Reus (Catalunya), Spain.

Abstract

Chronic liver diseases are accompanied by changes in the biochemical pathways related to the regulation of apoptosis and extra-cellular matrix deposition. The present study was designed to investigate, using low density arrays, changes in the hepatic gene expression together with hepatic biochemical and histological alterations in rats that had liver impairment induced by chronic exposure to CCl(4). Further, we examined the possible recovery of genetic and pathological changes following the cessation of the hepatotoxic injury. Experimental fibrosis was induced in male Wistar rats by CCl(4) administration. Animals were subdivided […]

30 01, 2008
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    Moderately high folic acid supplementation exacerbates experimentally induced liver fibrosis in rats.

Moderately high folic acid supplementation exacerbates experimentally induced liver fibrosis in rats.

By |January 30th, 2008|Publicacions|0 Comments|

Marsillach J, Ferré N, Camps J, Riu F, Rull A, Joven J.

Source
Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut de Recerca en Ciències de la Salut, Reus, Spain.

Abstract

Under certain clinical circumstances, folic acid can have undesirable effects. We investigated the following: (i) the effects of moderately high folic acid supplementation on the course of liver impairment in CCl(4)-treated rats and (ii) the influence of folic acid supplements on the hepatic recovery following the interruption of the CCl(4)-induced toxic injury. Four experimental groups of rats were used: CCl(4)-treated rats (0.5 ml of CCl(4) twice a week i.p.) fed standard chow for up to 12 weeks (Group A); treated rats fed chow supplemented with 25 mg/kg folic acid from weeks 6 to 12 (Group […]