Serum paraoxonase undergoes inhibition and proteolysis during experimental acute pancreatitis.

By |September 30th, 2008|Publicacions|0 Comments|

Franco-Pons N, Marsillach J, Joven J, Camps J, Closa D. Department of Ischemia and Inflammation, Institut d’Investigacions Biomèdiques de Barcelona (IIBB)-Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain. [email protected] Abstract Oxidative stress has a primary role in the pathogenesis of severe acute pancreatitis. Then, the antioxidant capacity is a critical factor in the progression of this disease. Serum paraoxonase-1 (PON1) is an esterase associated with high-density lipoprotein, which clinical interest resides in its ability to prevent or limit the lipid oxidation. The aim of this study was to investigate changes in PON1 activity in the early stages of acute pancreatitis and to find out if its alteration is related with the severity of the disease. […]