Monthly Archives: October 2010

30 10, 2010
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    Dilated aortic root is related to a global aortic dilating diathesis.

Dilated aortic root is related to a global aortic dilating diathesis.

By |October 30th, 2010|Publicacions|0 Comments|

Alegret JM, Calvo N, Ligero C, Palomares R, Millá L, Martín-Paredero V, Montero M, Joven J.

Source
Secció de Cardiologia, Hospital Universitari de Sant Joan, Reus, Spain. [email protected]

Abstract

OBJECTIVE:
The purpose of this study was to analyze the association between the dilatation of the aortic root and the diameters of the rest of the aorta and to identify some related factors that could be used to identify patients at higher risk of presenting with an aortic aneurysm.
METHODS:
In 71 consecutive patients with a dilated aortic root identified by transthoracic echocardiography, prospective helical computed tomography was performed. Aortic diameters were measured perpendicular to the flow at seven levels in the thoracic and abdominal aorta.
RESULTS:
Ascending aorta diameter showed a moderate correlation with aortic indexed diameters at the thoracic and abdominal level in tricuspid […]

30 10, 2010
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    Differential response of two models of genetically modified mice fed with high fat and cholesterol diets: relationship to the study of non-alcoholic steatohepatitis.

Differential response of two models of genetically modified mice fed with high fat and cholesterol diets: relationship to the study of non-alcoholic steatohepatitis.

By |October 30th, 2010|Publicacions|0 Comments|

Rodríguez-Sanabria F, Rull A, Aragonès G, Beltrán-Debón R, Alonso-Villaverde C, Camps J, Joven J.

Source
Centre de Recerca Biomèdica, Hospital Universitari Sant Joan de Reus, Universitat Rovira i Virgili, Reus, Spain.

Abstract

Research on the molecular basis of the hepatic alterations associated to obesity is dependent on the availability of suitable animal models. Apolipoprotein E deficient mice (ApoE(-/-)) and LDL-receptor deficient mice (LDLr(-/-)) develop steatosis and steatohepatitis when given pro-atherogenic diets. However, previous data suggest that these two models are not completely interchangeable, and that their metabolic phenotype may partially differ in response to nutrient stimuli. The present study further investigates this question, by comparing changes in hepatic inflammation, lipoprotein metabolism, and their related gene expressions. LDLr(-/-) mice were more susceptible to the development of obesity and hepatic steatosis, while the ApoE(-/-) model increased the amount of […]