Monthly Archives: March 2011

30 03, 2011

Immunohistochemical analysis of paraoxonases-1 and 3 in human atheromatous plaques.

By |March 30th, 2011|Publicacions|0 Comments|

Marsillach J, Camps J, Beltran-Debón R, Rull A, Aragones G, Maestre-Martínez C, Sabench F, Hernández M, Castillo DD, Joven J, Mackness M, Mackness B.

Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigacions Sanitàries Pere Virgili, Universitat Rovira i Virgili, Reus, Catalunya, Spain.


The paraoxonase (PON) enzyme family comprising PON1, PON2 and PON3 are antioxidant enzymes that degrade bioactive oxidised lipids and are thus antiatherogenic.
We investigated the localisation of the PON proteins during the development of atherosclerosis byimmunohistochemical analysis.
In normal aortas, PON1 and PON3 were localised to smooth muscle cells (SMC) and endothelial cells. PON3 staining was stronger than that of PON1. During atherosclerosis development, SMC staining for PON1 and PON3 was greatly reduced, while macrophage staining for both proteins increased with PON1 predominating. Macrophage staining for PON1 and […]

15 03, 2011
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    Continuous administration of polyphenols from aqueous rooibos (Aspalathus linearis) extract ameliorates dietary-induced metabolic disturbances in hyperlipidemic mice.

Continuous administration of polyphenols from aqueous rooibos (Aspalathus linearis) extract ameliorates dietary-induced metabolic disturbances in hyperlipidemic mice.

By |March 15th, 2011|Publicacions|0 Comments|

Beltrán-Debón R, Rull A, Rodríguez-Sanabria F, Iswaldi I, Herranz-López M, Aragonès G, Camps J, Alonso-Villaverde C, Menéndez JA, Micol V, Segura-Carretero A, Joven J.

Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, IISPV, Universitat Rovira i Virgili, Reus, Spain.


The incidence of obesity and related metabolic diseases is increasing globally. Current medical treatments often fail to halt the progress of suchdisturbances, and plant-derived polyphenols are increasingly being investigated as a possible way to provide safe and effective complementary therapy. Rooibos (Aspalathus linearis) is a rich source of polyphenols without caloric and/or stimulant components. We have tentatively characterized 25 phenolic compounds in rooibos extract and studied the effects of continuous aqueous rooibos extract consumption in mice. The effects of thisextract, which contained 25% w/w of total polyphenol content, were negligible in animals with no metabolic disturbance but were significant in hyperlipemic mice, especially in those in which energy intake was increased via a […]

3 03, 2011


By |March 3rd, 2011|Notícies|0 Comments|

La línea de investigación principal del Centre de Recerca Biomèdica de Reus, dirigido por el Dr. Jorge Joven, es el estudio de la inflamación y la oxidación en las enfermedades crónicas, como la obesidad, la esteatosis hepática y la aterosclerosis. En relación a esta última, el CRB viene colaborando desde hace varios años con el Servei d’Angiologia i Cirurgia Vascular del Hospital Universitari Joan XXIII de Tarragona en el estudio de la aterosclerosis periférica de miembros inferiores. El servicio, dirigido por el Dr. Vicente Martín Paredero, realiza numerosos trabajos de investigación, imparte cursos, ponencias y otros estudios.

Equipo del Servei d’Angiologia i Cirurgia Vascular, con el Dr. Martín Paredero a la izquierda.

Parte del equipo del Centre de Recerca Biomèdica, con […]

3 03, 2011

Nuevo artículo en el Diari de Tarragona: “La URV y el Hospital Sant Joan deben apostar más por la investigación”.

By |March 3rd, 2011|Notícies|0 Comments|

El Diari de Tarragona ha reunido a cuatro investigadores de la Facultat de Medicina i Ciències de la Salut de la URV, y han hablado sobre el futuro de la investigación en los próximos años. Aquí tenéis el artículo.

2 03, 2011

Nueva entrevista en el Diari de Tarragona

By |March 2nd, 2011|Notícies|0 Comments|

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