Monthly Archives: November 2011

3 11, 2011
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    Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer.

Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer.

By |November 3rd, 2011|Publicacions|0 Comments|

Menendez JA, Cufí S, Oliveras-Ferraros C, Martin-Castillo B, Joven J, Vellon L, Vazquez-Martin A. Source Translational Research Laboratory, Catalan Institute of Oncology, Girona, Catalonia, Spain. [email protected] Abstract By activating the ataxia telangiectasia mutated (ATM)-mediated DNA Damage Response (DDR), the AMPK agonist metformin might sensitize cellsagainst further damage, thus mimicking the precancerous stimulus that induces an intrinsic barrier against carcinogenesis. Herein, we present the new hypothesis that metformin might function as a tissue sweeper of pre-malignant cells before they gain stem cell/tumor initiating properties. Because enhanced glycolysis (the Warburg effect) plays a causal role in the gain of stem-like properties of tumor-initiating cells by protecting them from the pro-senescent effects of mitochondrial respiration-induced oxidative stress, metformin’s […]

1 11, 2011
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    Serum paraoxonase-3 concentration is associated with the severity of hepatic impairment in patients with chronic liver disease.

Serum paraoxonase-3 concentration is associated with the severity of hepatic impairment in patients with chronic liver disease.

By |November 1st, 2011|Publicacions|0 Comments|

García-Heredia A, Marsillach J, Aragonès G, Guardiola M, Rull A, Beltrán-Debón R, Folch A, Mackness B, Mackness M, Pedro-Botet J, Joven J, Camps J. Source Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, Catalonia, Spain. Abstract OBJECTIVES: Research on paraoxonase-3 (PON3) has been hampered by the lack of methods for measurement. This is a pilot study aimed at exploring whether chronic liver impairment is associated with changes in serum PON3 concentrations, and to know whether this measurement may provide useful information to investigate this derangement. DESIGN AND METHODS: We studied 110 patients with chronic liver disease understand usual. This overnight louis vuitton bibliography […]