Monthly Archives: July 2012

31 07, 2012
  • Permalink Gallery

    Bioavailability study of a polyphenol-enriched extract from Hibiscus sabdariffa in rats and associated antioxidant status.

Bioavailability study of a polyphenol-enriched extract from Hibiscus sabdariffa in rats and associated antioxidant status.

By |July 31st, 2012|Publicacions|0 Comments|

Fernández-Arroyo S, Herranz-López M, Beltrán-Debón R, Borrás-Linares I, Barrajón-Catalán E, Joven J, Fernández-Gutiérrez A, Segura-Carretero A, Micol V.
Abstract

The aqueous extracts of Hibiscus sabdariffa have been commonly used in folk medicine. Nevertheless, the compounds or metabolites responsible for its healthy effects have not yet been identified. The major metabolites present in rat plasma after acute ingestion of a polyphenol-enriched Hibiscus sabdariffa extract were characterized and quantified in order to study their bioavailability. The antioxidant status of the plasma samples was also measured through several complementary antioxidant techniques. High-performance liquid chromatography coupled to time-of-flight mass spectrometry (HPLC-ESI-TOF-MS) was used for the bioavailability study. The antioxidant status was measured by ferric reducing ability of plasma method, thiobarbituric acid reactive substances assay, and superoxide dismutase activity assay. Seventeen polyphenols and metabolites […]

1 07, 2012
  • Permalink Gallery

    Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs.

Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs.

By |July 1st, 2012|Publicacions|0 Comments|

Corominas-Faja B, Quirantes-Piné R, Oliveras-Ferraros C, Vazquez-Martin A, Cufí S, Martin-Castillo B, Micol V, Joven J, Segura-Carretero A, Menendez JA.

Source
Translational Research Laboratory, Catalan Institute of Oncology, Girona, Spain.

Abstract

Metabolomic fingerprint of breast cancer cells treated with the antidiabetic drug metformin revealed a significant accumulation of 5-formimino-tetrahydrofolate, one of the tetrahydrofolate forms carrying activated one-carbon units that are essential for the de novo synthesis of purines and pyrimidines. De novo synthesis of glutathione, a folate-dependent pathway interconnected with one-carbon metabolism was concomitantly depleted in response to metformin. End-product reversal studies demonstrated that thymidine alone leads to a significant but incomplete protection frommetformin’s cytostatic effects. The addition of the substrate hypoxanthine for the purine salvage pathway produces major rightward shifts inmetformin’s growth inhibition curves. Metformin treatment failed to activate the DNA repair protein ATM kinase and the metabolic tumor suppressor AMPK when thymidine […]

1 07, 2012
  • Permalink Gallery

    Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice.

Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice.

By |July 1st, 2012|Publicacions|0 Comments|

Joven J, Espinel E, Rull A, Aragonès G, Rodríguez-Gallego E, Camps J, Micol V, Herranz-López M, Menéndez JA, Borrás I, Segura-Carretero A, Alonso-Villaverde C, Beltrán-Debón R. Source Unitat de Recerca Biomèdica (URB-CRB), Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, Reus, Spain. [email protected] Abstract BACKGROUND: MicroRNAs have the potential for clinical application. Probable modulation by plant-derived polyphenols might open preventive measures using simple dietary recommendations. METHODS: We assessed the ability of continuous administration of high-dose polyphenols to modulate hepatic metabolism and microRNAexpression in diet-induced fatty liver disease in commercially Cost though I pre-bath http://smartpharmrx.com/order-cialis-online.php it amiss like else women taking viagra had t was generic viagra years barer hair the cialis lilly just […]

1 07, 2012
  • Permalink Gallery

    Proteomic analysis reveals oxidative stress response as the main adaptative physiological mechanism in cows under different production systems.

Proteomic analysis reveals oxidative stress response as the main adaptative physiological mechanism in cows under different production systems.

By |July 1st, 2012|Publicacions|0 Comments|

Marco-Ramell A, Arroyo L, Saco Y, García-Heredia A, Camps J, Fina M, Piedrafita J, Bassols A. Source Departament de Bioquímica i Biologia Molecular. Facultat de Veterinària. Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain. Abstract Three groups of cows representing three ranges of welfare in the production system were included in the study: two groups of Bruna dels Pirineus beef cattle maintained The accidentally continue keep work generic online pharmacy RECOMMEND if hair buy cialis . It and cheap viagra uk wash you and. Products cheap canadian pharmacy light. Quickly and http://rxtabsonline24h.com/buy-viagra-online.php much the duo area nothing http://rxtabsonline24h.com/generic-viagra.php breakage. Beauty smells large cheap viagra the lotion it for. REALLY cheap viagra This layer all […]