Monthly Archives: February 2014

27 02, 2014
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    Gerometabolites: The pseudohypoxic aging side of cancer oncometabolites.

Gerometabolites: The pseudohypoxic aging side of cancer oncometabolites.

By |February 27th, 2014|Publicacions|0 Comments|

Menendez JA1, Alarcón T2, Joven J3.

Author information

1 Metabolism & Cancer Group; Translational Research Laboratory; Catalan Institute of Oncology; Girona, Spain; Molecular Oncology Group; Girona Biomedical Research Institute (IDIBGI); Girona, Spain.
2 Computational & Mathematical Biology Research Group; Centre de Recerca Matemàtica (CRM); Barcelona, Spain.
3 Unitat de Recerca Biomèdica (URB-CRB); Institut d’Investigació Sanitaria Pere i Virgili (IISPV); Universitat Rovira i Virgili; Reus, Spain.

Abstract

Oncometabolites are defined as small-molecule components (or enantiomers) of normal metabolism whose accumulation causes signaling dysregulation to establish a milieu that initiates carcinogenesis. In a similar manner, we propose the term “gerometabolites” to refer to small-molecule components of normal metabolism whose depletion causes signaling dysregulation to establish a milieu that drives aging. In an investigation of the pathogenic activities of the […]

27 02, 2014
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    Polyphenols and the modulation of gene expression pathways: can we eat our way out of the danger of chronic disease?

Polyphenols and the modulation of gene expression pathways: can we eat our way out of the danger of chronic disease?

By |February 27th, 2014|Publicacions|0 Comments|

Joven J1, Micol V, Segura-Carretero A, Alonso-Villaverde C, Menéndez JA, For The Bioactive Food Components Platform.

Author information

1a Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, IISPV , Universitat Rovira i Virgili , Calle Sant Llorenç 21 , 43201 , Reus , Spain.

Abstract

Plant-derived dietary polyphenols may improve some disease states and promote health. Experimental evidence suggests that this is partially attributable to changes in gene expression. The rational use of bioactive food components may therefore present an opportunity to activate or repress selected gene expression pathways and, consequently, to manage or prevent disease. It remains to be determined whether this use of bioactive food components can be done safely. This article reviews the associated controversies and limitations of polyphenol therapy. There is a paucity […]

27 02, 2014
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    Rosiglitazone and Fenofibrate Exacerbate Liver Steatosis in a Mouse Model of Obesity and Hyperlipidemia. A Transcriptomic and Metabolomic Study.

Rosiglitazone and Fenofibrate Exacerbate Liver Steatosis in a Mouse Model of Obesity and Hyperlipidemia. A Transcriptomic and Metabolomic Study.

By |February 27th, 2014|Publicacions|0 Comments|

Rull A1, Geeraert B, Aragonès G, Beltrán-Debón R, Rodríguez-Gallego E, García-Heredia A, Pedro-Botet J, Joven J, Holvoet P, Camps J.

Author information
1) Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201 Reus, Spain ; Campus of International Excellence Southern Catalonia, Spain

Abstract

Peroxisome proliferator-activated receptors (PPAR) play an important role in the regulation of lipid and glucose metabolism, inflammatory, and vascular responses. We show the effect of treatment with two PPAR agonists, fenofibrate (FF) and rosiglitazone (RSG), on ob/ob and LDLR-double deficient mice, by combined gene-expression and metabolomic analyses. Male mice were daily treated for 12 weeks with RSG (10 mg·kg1-·day-1 per os (p.o.), n = 8) and FF (50 mg·kg1-·day-1 p.o., n = 8). Twelve untreated ob/ob and LDLR-double deficient […]

27 02, 2014
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    Ubiquitous transgenic overexpression of C-C chemokine ligand 2: a model to assess the combined effect of high energy intake and continuous low-grade inflammation.

Ubiquitous transgenic overexpression of C-C chemokine ligand 2: a model to assess the combined effect of high energy intake and continuous low-grade inflammation.

By |February 27th, 2014|Publicacions|0 Comments|

Rodríguez-Gallego E1, Riera-Borrull M1, Hernández-Aguilera A1, Mariné-Casadó R1, Rull A1, Beltrán-Debón R1, Luciano-Mateo F1, Menendez JA2, Vazquez-Martin A2, Sirvent JJ3, Martín-Paredero V4, Corbí AL5, Sierra-Filardi E5, Aragonès G1, García-Heredia A1, Camps J1, Alonso-Villaverde C6, Joven J1. Author information 1) Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201 Reus, Spain ; Campus of International Excellence Southern Catalonia, Spain 2) Catalan Institute of Oncology and Girona Biomedical Research Institute, Avda de Francia s/n, 17007 Girona, Spain. 3) Department of Pathology, Hospital Universitari Joan XXIII, C/ Dr. Mallafrè Guasch 4, 43005 Tarragona, Spain 4) Department of Vascular Surgery, Hospital Universitari Joan XXIII, C/ Dr. Mallafrè Guasch 4, […]

27 02, 2014
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    Treat-to-Target Low-Density Lipoprotein Cholesterol: Time to Debate a Too Simple and Dogmatic Paradigm.

Treat-to-Target Low-Density Lipoprotein Cholesterol: Time to Debate a Too Simple and Dogmatic Paradigm.

By |February 27th, 2014|Publicacions|0 Comments|

 
Joven J, Martin-Paredero V, Camps J.

Author information
Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan and Hospital Universitari Joan XXIII, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.

PMID: 24163119

26 02, 2014
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    Una planta que sobreviu al desert ajuda els humans a viure més anys

Una planta que sobreviu al desert ajuda els humans a viure més anys

By |February 26th, 2014|Notícies|0 Comments|

En data 26 de Febrer, s’ha publicat la següent notícia al web ComCiència, de la Universitat Rovira i Virgili (URV) així com també al web del CEICS i del Diari Digital de la mateixa.

– ComCiència (català): Aquí

– ComCiència (castellà): Aquí

– CEICS (català): Aquí

– CEICS (castellà): Aquí

– Diari Digital de la URV: Aquí