Monthly Archives: January 2015

19 01, 2015
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    El consumo de derivados de la stevia frena el cúmulo de grasa en el hígado

El consumo de derivados de la stevia frena el cúmulo de grasa en el hígado

By |January 19th, 2015|Notícies|0 Comments|

En data 14 de gener de 2015, es va publicar la següent notícia al Diari de Tarragona:

Clic aquí per a l’enllaç web.

Clic aquí per al PDF de la notícia

 

En fecha 14 de Enero de 2015, se publicó la siguente noticia en el Diari de Tarragona:

Clic aquí para el enlace web.

Clic aquí para el PDF de la noticia.

 

 

19 01, 2015
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    Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: A transcriptomic and metabolomic study

Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: A transcriptomic and metabolomic study

By |January 19th, 2015|Publicacions|0 Comments|

Holvoet P1, Rull A2, García-Heredia A2, López-Sanromà S2, Geeraert B3, Joven J2, Camps J2.

Author information

1Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Leuven, Belgium. Electronic address: [email protected]
2Unitat de Recerca Biomèdica (CRB-URB), Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, Reus, Spain.
3Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Leuven, Belgium

Abstract

There is a close interaction between Type 2 Diabetes, obesity and liver disease. We have studied the effects of the two most abundant Stevia-derived steviol glycosides, stevioside and rebaudioside A, and their aglycol derivative steviol on liver steatosis and the hepatic effects of lipotoxicity using a mouse model of obesity and insulin resistance. We treated ob/ob and […]

19 01, 2015
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    Exercise in a hot environment influences plasma anti-inflammatory and antioxidant status in well-trained athletes

Exercise in a hot environment influences plasma anti-inflammatory and antioxidant status in well-trained athletes

By |January 19th, 2015|Publicacions|0 Comments|

Sureda A1, Mestre-Alfaro A1, Banquells M2, Riera J2, Drobnic F2, Camps J3, Joven J3, Tur JA1, Pons A4.

Author information

1Laboratory of Physical Activity Science, University of the Balearic Islands, Palma de Mallorca, Spain and CIBER Fisiopatología de la Obesidad y la Nutrición, CIBERobn, Instituto de Salud Carlos III (ISCIII), Spain.
2Sports Physiology Dept., High Performance Centre of San Cugat del Vallés, Barcelona, Spain.
3Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.
4Laboratory of Physical Activity Science, University of the Balearic Islands, Palma de Mallorca, Spain and CIBER Fisiopatología de la Obesidad y la Nutrición, CIBERobn, Instituto de Salud Carlos III (ISCIII), Spain. Electronic address: [email protected]

Abstract

Exercise in thermally stressful environmental conditions can […]

19 01, 2015
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    Exploring the role of paraoxonases in the pathogenesis of coronary artery disease: a systematic review

Exploring the role of paraoxonases in the pathogenesis of coronary artery disease: a systematic review

By |January 19th, 2015|Publicacions|0 Comments|

Abelló D, Sancho E, Camps J, Joven J.

Author information

Department of Medicine and Surgery, Faculty of Medicine and Health Sciences, Rovira i Virgili University, C. Sant Llorenç, s/n, Reus, Catalonia 43201, Spain.

Abstract

Paraoxonases (PON) are three enzymes (PON1, PON2 and PON3) that play a role in the organism’s antioxidant system; alterations in which are associated with diseases involving oxidative stress. In this review, we summarize the evidence of PON related to the pathogenesis of coronary artery disease (CAD) and atherosclerosis. We searched three electronic databases (PubMed, Scopus and Cochrane Database) with no date limit. All of the articles selected investigated PON enzymatic activity and/or PON gene polymorphisms. The selection focused on PON in relation to atherosclerosis, CAD and myocardial infarction. The […]

19 01, 2015
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    Understanding the role of circulating chemokine (C-C motif) ligand 2 in patients with chronic ischemia threatening the lower extremities

Understanding the role of circulating chemokine (C-C motif) ligand 2 in patients with chronic ischemia threatening the lower extremities

By |January 19th, 2015|Publicacions|0 Comments|

Rull A1, Hernandez-Aguilera A2, Fibla M3, Sepulveda J4, Rodríguez-Gallego E1, Riera-Borrull M1, Sirvent JJ3, Martín-Paredero V4, Menendez JA5, Camps J1, Joven J6.

Author information

1Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.
2Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain Servei d’Angiologia, Cirurgia Vascular i Endovascular, Hospital Universitari Joan XXIII, Tarragona, Spain.
3Servei d’Anatomia Patològica, Hospital Universitari Joan XXIII, Tarragona, Spain.
4Servei d’Angiologia, Cirurgia Vascular i Endovascular, Hospital Universitari Joan XXIII, Tarragona, Spain.
5Molecular Oncology Group, Girona Biomedical Research Institute (IDIBGI), Girona, Spain.
6Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, […]

19 01, 2015
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    Computer-aided discovery of biological activity spectra for anti-aging and anti-cancer olive oil oleuropeins

Computer-aided discovery of biological activity spectra for anti-aging and anti-cancer olive oil oleuropeins

By |January 19th, 2015|Publicacions|0 Comments|

Corominas-Faja B1, Santangelo E2, Cuyàs E1, Micol V3, Joven J4, Ariza X2, Segura-Carretero A5, García J2, Menendez JA

Author information

1Metabolism and Cancer Group, Translational Research Laboratory, Catalan Institute of Oncology (ICO), Girona, Spain. Girona Biomedical Research Institute (IDIBGI), Girona, Spain.
2Departament de Química Orgànica, Fac. de Química, Institut de Biomedicina de la UB (IBUB), Universitat de Barcelona, Barcelona, Spain.
3Instituto de Biología Molecular y Celular (IBMC), Universidad Miguel Hernández, Elche, Alicante, Spain.
4Campus of International Excellence Southern Catalonia, Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.
5Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Granada, Spain; Functional Food Research and Development Centre (CIDAF), PTS Granada, Granada, Spain

Abstract

Aging is associated with […]

19 01, 2015
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    Molecular promiscuity of plant polyphenols in the management of age-related diseases: far beyond their antioxidant properties

Molecular promiscuity of plant polyphenols in the management of age-related diseases: far beyond their antioxidant properties

By |January 19th, 2015|Publicacions|0 Comments|

Barrajón-Catalán E, Herranz-López M, Joven J1, Segura-Carretero A, Alonso-Villaverde C, Menéndez JA, Micol V.

Author information

1 Unitat de Recerca Biomèdica (URB-CRB), IISPV, Hospital Universitari de Sant Joan, Universitat Rovira i Virgili, Reus, Tarragona.

Abstract

The use of plant-derived polyphenols for the management of diseases has been under debate in the last decades. Most studies have focused on the specific effects of polyphenols on particular targets, while ignoring their pleiotropic character. The multitargeted character of polyphenols, a plausible consequence of their molecular promiscuity, may suppose an opportunity to fight multifactorial diseases. Therefore, a wider perspective is urgently needed to elucidate whether their rational use as bioactive food components may be valid for the management of diseases. In this chapter, we discuss the most […]

19 01, 2015
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    Energy metabolism and metabolic sensors in stem cells: the metabostem crossroads of aging and cancer

Energy metabolism and metabolic sensors in stem cells: the metabostem crossroads of aging and cancer

By |January 19th, 2015|Publicacions|0 Comments|

Menendez JA1, Joven J.

Author information

1 Unitat de Recerca Biomèdica (URB-CRB), IISPV, Hospital Universitari de Sant Joan, Universitat Rovira i Virgili, Reus, Tarragona, España.

Abstract

We are as old as our adult stem cells are; therefore, stem cell exhaustion is considered a hallmark of aging. Our tumors are as aggressive as the number of cancer stem cells (CSCs) they bear because CSCs can survive treatments with hormones, radiation, chemotherapy, and molecularly targeted drugs, thus increasing the difficulty of curing cancer. Not surprisingly, interest in stem cell research has never been greater among members of the public, politicians, and scientists. But how can we slow the rate at which our adult stem cells decline over our lifetime, reducing the regenerative potential of tissues, […]

19 01, 2015
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    Autophagy is an inflammation-related defensive mechanism against disease

Autophagy is an inflammation-related defensive mechanism against disease

By |January 19th, 2015|Publicacions|0 Comments|

Joven J1, Guirro M, Mariné-Casadó R, Rodríguez-Gallego E, Menéndez JA.

Author information

1 Unitat de Recerca Biomèdica (URB-CRB), IISPV, Hospital Universitari de Sant Joan, Universitat Rovira i Virgili, Reus, Tarragona, España.

Abstract

The inflammatory response is an energy-intensive process. Consequently, metabolism is closely associated with immune function. The autophagy machinery plays a role in metabolism by providing energy but may also be used to attack invading pathogens (xenophagy). The autophagy machinery may function to protect against not only the threats of infection but also the threats of the host’s own response acting on the central immunological tolerance and the negative regulation of innate and inflammatory signaling. The balance between too little and too much autophagy is critical for the survival of immune cells […]

19 01, 2015
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    Oncobiguanides: Paracelsus’ law and nonconventional routes for administering diabetobiguanides for cancer treatment

Oncobiguanides: Paracelsus’ law and nonconventional routes for administering diabetobiguanides for cancer treatment

By |January 19th, 2015|Publicacions|0 Comments|

Menendez JA1, Quirantes-Piné R, Rodríguez-Gallego E2, Cufí S, Corominas-Faja B, Cuyàs E, Bosch-Barrera J, Martin-Castillo B, Segura-Carretero A, Joven J2.

Author information

1Metabolism & Cancer Group, Translational Research Laboratory, Catalan Institute of Oncology, Girona (ICO-Girona), Hospital Dr. Josep Trueta de Girona, Ctra. França s/n, E-17007, Girona, Catalonia, Spain.
2 Unitat de Recerca Biomèdica (URB-CRB), IISPV, Hospital Universitari de Sant Joan, Universitat Rovira i Virgili, Reus, Tarragona, España.

Abstract

“The dose makes the poison”, the common motto of toxicology first expressed by Paracelsus more than 400 years ago, may effectively serve to guide potential applications for metformin and related biguanides in oncology. While Paracelsus’ law for the dose-response effect has been commonly exploited for the use of some anti-cancer drugs at lower doses in non-neoplastic […]